Wordprocessing Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation

Authors: Lorenz Adlung, Sandip Kar, Marie-Christine Wagner, Bin She, Sajib Chakraborty, Jie Bao, Susen Lattermann, Melanie Boerries, Hauke Busch, Patrick Wuchter, Anthony D Ho, Jens Timmer, Marcel Schilling, Thomas Höfer, Ursula Klingmüller

DOI: 10.15252/msb.20167258

Date Published: 24th Jan 2017

Abstract (Expand)

Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, ...

Created: 31st Jan 2017 at 13:58   Last updated: 31st Jan 2017 at 14:00

Wordprocessing Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells

Authors: Ruth Merkle, Bernhard Steiert, Florian Salopiata, Sofia Depner, Andreas Raue, Nao Iwamoto, Max Schelker, Helge Hass, Marvin Wäsch, Martin E. Böhm, Oliver Mücke, Daniel B. Lipka, Christoph Plass, Wolf D. Lehmann, Clemens Kreutz, Jens Timmer, Marcel Schilling, Ursula Klingmüller

DOI: 10.1371/journal.pcbi.1005049

Date Published: 5th Aug 2016

Abstract (Expand)

Lung cancer, with its most prevalent form non-small-cell lung carcinoma (NSCLC), is one of the leading causes of cancer-related deaths worldwide, and is commonly treated with chemotherapeutic drugs ...

Created: 13th Dec 2016 at 11:28   Last updated: 13th Dec 2016 at 11:29

Wordprocessing Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells

Authors: P. Wuchter, M. Vetter, Rainer Saffrich, A. Diehlmann, K. Bieback, A. D. Ho, P. Horn

PubMed ID: 26911671

Date Published: 26th Feb 2016

Abstract (Expand)

Mesenchymal stromal cells (MSCs) from human bone marrow serve as a resource for cell-based therapies in regenerative medicine. Clinical applications require standardized protocols according to good ...

Created: 11th May 2016 at 11:15

Wordprocessing Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells

Authors: P. Wuchter, Rainer Saffrich, S. Giselbrecht, C. Nies, H. Lorig, S. Kolb, A. D. Ho, E. Gottwald

PubMed ID: 26829941

Date Published: 30th Jan 2016

Abstract (Expand)

In previous studies human mesenchymal stromal cells (MSCs) maintained the "stemness" of human hematopoietic progenitor cells (HPCs) through direct cell-cell contact in two-dimensional co-culture ...

Created: 11th May 2016 at 11:14

Wordprocessing Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications

Authors: P. Wuchter, K. Bieback, H. Schrezenmeier, M. Bornhauser, L. P. Muller, H. Bonig, W. Wagner, R. Meisel, P. Pavel, T. Tonn, P. Lang, I. Muller, M. Renner, G. Malcherek, Rainer Saffrich, E. C. Buss, P. Horn, M. Rojewski, A. Schmitt, A. D. Ho, R. Sanzenbacher, M. Schmitt

PubMed ID: 24856898

Date Published: 20th May 2014

Abstract (Expand)

BACKGROUND AIMS: Human mesenchymal stem or stromal cells (MSCs) represent a potential resource not only for regenerative medicine but also for immunomodulatory cell therapies. The application of different ...

Created: 11th May 2016 at 11:13


Wordprocessing Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells

Authors: G. Malcherek, N. Jin, A. G. Huckelhoven, J. Mani, L. Wang, U. Gern, A. Diehlmann, P. Wuchter, A. Schmitt, B. Chen, A. D. Ho, M. Schmitt

PubMed ID: 25227910

Date Published: 17th Sep 2014

Abstract (Expand)

Mesenchymal stromal cells (MSCs) possess broad immunomodulatory capacities that are currently investigated for potential clinical application in treating autoimmune disorders. Third-party MSCs suppress ...

Created: 11th May 2016 at 11:10

Wordprocessing Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation

Authors: N. Iwamoto, L. A. D'Alessandro, S. Depner, B. Hahn, B. A. Kramer, P. Lucarelli, A. Vlasov, M. Stepath, M. E. Bohm, D. Deharde, G. Damm, D. Seehofer, W. D. Lehmann, U. Klingmuller, Marcel Schilling

PubMed ID: 26838549

Date Published: 4th Feb 2016

Abstract (Expand)

The same pathway, such as the mitogen-activated protein kinase (MAPK) pathway, can produce different cellular responses, depending on stimulus or cell type. We examined the phosphorylation dynamics of ...

Created: 28th Apr 2016 at 13:22

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